Ethyl (E)-3-(1,4-dimethoxy-3-methylsulfanylnaphthalen-2-yl)-2-methylpropenoate → (E)-3-(1,4-dimethoxy-3-methylsulfanylnaphthalen-2-yl)-2-methylpropenoic acid

HRID 1527693ノート

反応式

HRID 1527693 の反応式
[CH3:1][O:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([O:13][CH3:14])=[C:5]([S:15][CH3:16])[C:4]=1/[CH:17]=[C:18](\[CH3:24])/[C:19]([O:21]CC)=[O:20].COC1C2C(=CC=CC=2)C(OC)=CC=1/C=C(\C)/C(O)=O>CCOC(C)=O>[CH3:1][O:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([O:13][CH3:14])=[C:5]([S:15][CH3:16])[C:4]=1/[CH:17]=[C:18](\[CH3:24])/[C:19]([OH:21])=[O:20]

参加物

4

反応物 2

HCID 46180104Ethyl (E)-3-(1,4-dimethoxy-3-methylsulfanylnaphthalen-2-yl)-2-methylpropenoateHCID 46180242(E)-3-(1,4-dimethoxynaphthalen-2-yl)-2-methylpropenoic acid

生成物 1

HCID 46180316(E)-3-(1,4-dimethoxy-3-methylsulfanylnaphthalen-2-yl)-2-methylpropenoic acid

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

Compound 99h was prepared from 98h (0.165 g, 0.476 mmol) as described above for 29a to give 0.181 g (0.568 mmol, 118%) of the product as a orange solid following flash chromatography (1:3 EtOAc:hexanes 0.5% AcOH) and recrystallization from Et2O/hexanes.

後処理

  1. customto give

出典と根拠

ORDレコード
ord-ebd4fdbc914f4b67b0196926c3bb7f31
出典データセット
uspto-grants-2015_07
特許番号
US09089605B2

反応ノート

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