Dichloromethane → Ethyl (2R/S)-3-(3-bromo-1,4-naphthoquinon-2-yl)-2-methylpropionate

HRID 1527715ノート

反応式

HRID 1527715 の反応式
[Br:1][C:2]1[C:3]([CH2:16][CH:17]([CH3:23])[C:18]([O:20][CH2:21][CH3:22])=[O:19])=[C:4]([O:14]C)[C:5]2[C:10]([C:11]=1[O:12]C)=[CH:9][CH:8]=[CH:7][CH:6]=2.BrC1C(=O)C2C(=CC=CC=2)C(=O)C=1C(C)C(OCC)=O.C(Cl)Cl>CCCCCC>[Br:1][C:2]1[C:11](=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:14])[C:3]=1[CH2:16][CH:17]([CH3:23])[C:18]([O:20][CH2:21][CH3:22])=[O:19]

参加物

5

反応物 3

HCID 6344DichloromethaneHCID 70835186Ethyl (2R/S)-3-(3-bromo-1,4-dimethoxynaphthalen-2-yl)-2-methylpropionateHCID 86647738Ethyl (3-bromo-1,4-naphthoquinon-2-yl)-propionate

生成物 1

HCID 70835151Ethyl (2R/S)-3-(3-bromo-1,4-naphthoquinon-2-yl)-2-methylpropionate

試薬・触媒・溶媒 1

HCID 8058Hexane溶媒

実験手順

Compound 68b was prepared from 67b (0.258 g, 0.678 mmol) as described above for 68a to give 0.064 g (0.18 mmol, 27%) of the product as a yellow solid following flash chromatography (3:1 CH2Cl2:hexane).

出典と根拠

ORDレコード
ord-21c7d5fe473440338d8a0debf62076a8
出典データセット
uspto-grants-2015_07
特許番号
US09089605B2

反応ノート

読み込み中…