1-(3-Chlorophenyl)piperazine → Methyl {2-[4-(3-chlorophenyl)piperazin-1-yl]-3-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrido[3,4-d]pyrimidin-4-yl}acetate

反応式

[Cl:26][c:27]1[cH:28][c:29]([N:33]2[CH2:34][CH2:35][NH:36][CH2:37][CH2:38]2)[cH:30][cH:31][cH:32]1.[F:1][C:2]([c:3]1[cH:4][c:5]([N:9]=[C:10]=[N:11][c:12]2[cH:13][n:14][cH:15][cH:16][c:17]2[CH:18]=[CH:19][C:20](=[O:21])[O:22][CH3:23])[cH:6][cH:7][cH:8]1)([F:24])[F:25]>>[F:1][C:2]([c:3]1[cH:4][c:5]([N:9]2[C:10]([N:36]3[CH2:35][CH2:34][N:33]([c:29]4[cH:28][c:27]([Cl:26])[cH:32][cH:31][cH:30]4)[CH2:38][CH2:37]3)=[N:11][c:12]3[cH:13][n:14][cH:15][cH:16][c:17]3[CH:18]2[CH2:19][C:20](=[O:21])[O:22][CH3:23])[cH:6][cH:7][cH:8]1)([F:24])[F:25]

参加物

反応物 2

HCID 13551-(3-Chlorophenyl)piperazine

HCID 90761513Methyl 3-[3-[[3-(trifluoromethyl)phenyl]iminomethylideneamino]-4-pyridinyl]prop-2-enoate

生成物 1

HCID 59168057Methyl {2-[4-(3-chlorophenyl)piperazin-1-yl]-3-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrido[3,4-d]pyrimidin-4-yl}acetate

出典と根拠

ORDレコード: ord-69b7fe457e4241a5bf8ba73a508468cc
出典データセット: Training data from https://doi.org/10.1039/C8SC04228D (9/10)
DOI: 10.1039/C8SC04228D

反応ノート

読み込み中…