Menadione → HCID 67057787、化合物

反応式

[CH3:1][C:2]1[C:12](=[O:13])[C:11]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=2[C:4](=[O:5])[CH:3]=1.[Br:14][C:15]1[CH:20]=[C:19]([O:21][CH3:22])[CH:18]=[CH:17][C:16]=1[CH2:23]C(O)=O>>[Br:14][C:15]1[CH:20]=[C:19]([O:21][CH3:22])[CH:18]=[CH:17][C:16]=1[CH2:23][C:3]1[C:4](=[O:5])[C:6]2[C:11]([C:12](=[O:13])[C:2]=1[CH3:1])=[CH:10][CH:9]=[CH:8][CH:7]=2

参加物

反応物 2

HCID 4055Menadione

HCID 39636682-Bromo-4-methoxyphenylacetic acid

生成物 1

HCID 67057787HCID 67057787、化合物収率 57%

実験手順

As starting materials for the coupling reaction menadione and 2-Bromo-4-methoxyphenylacetic acid were used. Synthesis is realized according to the general procedure described in general procedure of example 1. After chromatography on silica gel (petroleum ether:CH2Cl2=1:1, UV), 857 mg (2.31 mmol, 57% yield) of P_TM102 were isolated as yellow oil.

後処理

customSynthesis

出典と根拠

ORDレコード: ord-c3cb222614f94c5abf59bb1144230a8d
出典データセット: uspto-grants-2015_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09090549B2

反応ノート

読み込み中…

参加物