Dimethylformamide dimethyl acetal → HCID 86686550、化合物

HRID 1528058ノート

反応式

HRID 1528058 の反応式
[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([N:15]2[CH:19]=[C:18]([F:20])[C:17]([F:21])=[CH:16]2)[CH:12]=[CH:11][C:10]=1[NH:22][N:23]=[C:24]([C:29](=[O:33])[CH2:30][O:31][CH3:32])[C:25]([O:27][CH3:28])=[O:26])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:34]OC(OC)N(C)C>>[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([N:15]2[CH:19]=[C:18]([F:20])[C:17]([F:21])=[CH:16]2)[CH:12]=[CH:11][C:10]=1[N:22]1[CH:34]=[C:30]([O:31][CH3:32])[C:29](=[O:33])[C:24]([C:25]([O:27][CH3:28])=[O:26])=[N:23]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

3

反応物 2

HCID 78373Dimethylformamide dimethyl acetalHCID 178496279HCID 178496279、化合物

生成物 1

HCID 86686550HCID 86686550、化合物

実験手順

A mixture of methyl 2-{[2-(benzyloxy)-4-(3,4-difluoro-1H-pyrrol-1-yl)phenyl]hydrazono}-4-methoxy-3-oxobutanoate (4.85 g) and N,N-dimethylformamide dimethyl acetal (100 mL) was heated under reflux for 3 hr. The mixture was allowed to be cooled to room temperature, and the precipitate was collected by filtration, and recrystallized from methanol to give the title compound (4.57 g).

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 3 hr
  3. filtrationthe precipitate was collected by filtration
  4. customrecrystallized from methanol

出典と根拠

ORDレコード
ord-73e61775898445eab5cf791643266ed4
出典データセット
uspto-grants-2015_07
特許番号
US09090586B2

反応ノート

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