Dimethyl Sulfone → Pyridine, 2-bromo-6-[(methylsulfonyl)methyl]-

反応式

[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4](F)[N:3]=1.[CH3:9][S:10]([CH3:13])(=[O:12])=[O:11]>>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH2:9][S:10]([CH3:13])(=[O:12])=[O:11])[N:3]=1

参加物

反応物 2

HCID 6213Dimethyl Sulfone

HCID 6394382-Bromo-6-fluoropyridine

生成物 1

HCID 59526086Pyridine, 2-bromo-6-[(methylsulfonyl)methyl]-収率 70%

実験手順

The title compound was prepared from 2-bromo-6-fluoro-pyridine and dimethylsulfone following a procedure analogous to that described in Step 1 for Intermediate 14. Yield: ca. 70% of theory (crude); LC (method 3): tR=1.98 min; Mass spectrum (ESI+): m/z=250/252 (Br) [M+H]+.

出典と根拠

ORDレコード: ord-800b6d0e7be94938b77ee33523bbb193
出典データセット: uspto-grants-2015_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09090605B2

反応ノート

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