Triethyl phosphite → 5-Bromo-6-chlorobenzo[c][1,2,5]oxadiazole

HRID 1529501ノート

反応式

HRID 1529501 の反応式
P(OCC)(OCC)OCC.[Br:11][C:12]1[C:13]([Cl:22])=[CH:14][C:15]2[C:16]([CH:21]=1)=[N+:17]([O-])[O:18][N:19]=2.[O-]Cl.[Na+]>C(O)C>[Br:11][C:12]1[C:13]([Cl:22])=[CH:14][C:15]2=[N:19][O:18][N:17]=[C:16]2[CH:21]=1

参加物

5

反応物 3

HCID 31215Triethyl phosphiteHCID 23665760Sodium HypochloriteHCID 674650696-Bromo-5-chlorobenzo[c][1,2,5]oxadiazole 1-oxide

生成物 1

HCID 674684685-Bromo-6-chlorobenzo[c][1,2,5]oxadiazole

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
79 °C

実験手順

P(OEt)3 (0.9 mL, 903 mg, 5.4 mmol) was added to a solution of bromide 93 (904 mg, 3.6 mmol) in ethanol at 79° C. The resulting mixture was stirred at 79° C. for 4 h. The mixture was then cooled in an ice bath and NaOCl (19 mL of a 10-15% sol, 1.2 g, 16 mmol) was added. The solution was cooled and concentrated under reduced pressure to provided crude 94.

後処理

  1. temperatureThe mixture was then cooled in an ice bath
  2. temperatureThe solution was cooled
  3. concentrationconcentrated under reduced pressure
  4. customto provided crude 94

出典と根拠

ORDレコード
ord-f9c3f209edbf42ca858d5f38ec4a73e0
出典データセット
uspto-grants-2015_07
特許番号
US09090612B2

反応ノート

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