Hydrochloric Acid → (R)-(R)-quinuclidin-3-yl 2-amino-2-phenylacetate bis hydrochloride
反応式
C(OC([NH:8][C@H:9]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C:10]([O:12][C@@H:13]1[CH:18]2[CH2:19][CH2:20][N:15]([CH2:16][CH2:17]2)[CH2:14]1)=[O:11])=O)(C)(C)C.[ClH:27].C(OCC)C>O1CCOCC1>[ClH:27].[ClH:27].[NH2:8][C@H:9]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C:10]([O:12][C@@H:13]1[CH:18]2[CH2:17][CH2:16][N:15]([CH2:20][CH2:19]2)[CH2:14]1)=[O:11]参加物
5
実験手順
To a solution of (R)—(R)-quinuclidin-3-yl 2-((tert-butoxycarbonyl)amino)-2-phenylacetate (0.608 g, 1.687 mmol) in anhydrous dioxane (6 mL) was added 2M HCl in diethyl ether (5.2 mL, 10.4 mmol). The reaction mixture was stirred at room temperature for 20 hours. The solvent was removed in vacuo to afford the title compound as a white solid (0.564 g, quantitative yield).