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HRID 15304作成日：2026年10月27日

Tetrafluoro-m-phenylenediamine dihydrochloride → Racemic 3-chloro-4-[(4-{[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-yl)methyl]amino}-1-piperidinyl)methyl]-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one dihydrochloride

https://huagongshe.com/reaction/15304

反応式

関与物質

役割名称HCID仕込み量
反応物Tetrafluoro-m-phenylenediamine dihydrochlorideHCID 149026—
反応物Ether hydrochlorideHCID 10953452—
反応物Racemic 3-chloro-4-[(4-{[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-yl)methyl]amino}-1-piperidinyl)methyl]-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-oneHCID 24871549—
溶媒ChloroformHCID 6212—
生成物Racemic 3-chloro-4-[(4-{[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-yl)methyl]amino}-1-piperidinyl)methyl]-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one dihydrochlorideHCID 68685184—

反応手順

Racemic 3-chloro-4-[(4-{[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-yl)methyl]amino}-1-piperidinyl)methyl]-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one was converted to the dihydrochloride by dissolving in chloroform and adding 1M HCl/diethyl ether then evaporating to dryness. MS as that of free base.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07732461B2
出典データセットuspto-grants-2010_06
ORD IDord-5c06d8d3ee3c47bbbd4173856818d6b2
出典メモuspto-grants-2010_06