Boron tribromide → 3-Fluoro-4,5-dihydroxybenzaldehyde

HRID 15307ノート

反応式

HRID 15307 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([O:11]C)[C:9]=1[OH:10])[CH:5]=[O:6].B(Br)(Br)Br>ClCCl>[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([OH:11])[C:9]=1[OH:10])[CH:5]=[O:6]

参加物

4

反応物 2

HCID 25134Boron tribromideHCID 5984523-Fluoro-4-hydroxy-5-methoxybenzaldehyde

生成物 1

HCID 5936643-Fluoro-4,5-dihydroxybenzaldehyde収率 14.4%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 3-fluoro-4-hydroxy-5-(methyloxy)benzaldehyde (5.0 g, 29.4 mmol) in dichloromethane (80 ml) at 0° C. was added boron tribromide (43 ml, 1M solution in dichloromethane) dropwise and then the reaction was allowed to stir for 1 h at rt before the solvent was removed under reduced pressure and the residue acidified with aqueous HCl (1M). The resultant solid was filtered, washed with water and dried in vacuo to give the desired compound (0.66 g, 14%).

後処理

  1. customwas removed under reduced pressure
  2. filtrationThe resultant solid was filtered
  3. washwashed with water
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-4c41217c3547423eb3c49cdf8fa1846b
出典データセット
uspto-grants-2010_06
特許番号
US07732461B2

反応ノート

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