HCID 54173602、化合物 → HCID 13885606、化合物

HRID 1530748ノート

反応式

HRID 1530748 の反応式
[O:1]([C:8]1[CH:9]=[C:10]([CH2:14][CH2:15][CH:16]=[C:17]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:18]([F:21])([F:20])[F:19])[CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H][H]>C(O)C.[Ni]>[O:1]([C:8]1[CH:9]=[C:10]([CH2:14][CH2:15][CH2:16][CH:17]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:18]([F:19])([F:20])[F:21])[CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 2

HCID 54173602HCID 54173602、化合物HCID 178418361HCID 178418361、化合物2 回

生成物 1

HCID 13885606HCID 13885606、化合物

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 702Ethanol溶媒

実験手順

4-(3-Phenoxyphenyl)-1-phenyl-1-trifluoromethyl-1-butene (3.18 g; 8.6 mmol) was hydrogenated in ethanol (40 ml) with hydrogen with the addition of Raney nickel (0.4 g) at room temperature and under atmospheric pressures. After the calculated amount of hydrogen had been taken up, the catalyst was filtered off and the solvent removed under reduced pressure. After chromatography on silica gel with hexane/toluene, there remained 2.49 g of product (=78% of theory).

後処理

  1. filtrationthe catalyst was filtered off
  2. customthe solvent removed under reduced pressure

出典と根拠

ORDレコード
ord-30298c6f27244d23a3949a9eb7a69afe
出典データセット
uspto-grants-2001_03
特許番号
USRE037087E1

反応ノート

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