反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([OH:11])[C:9]=1[OH:10])[CH:5]=[O:6].C(=O)([O-])[O-].[K+].[K+].Br[CH2:19][CH2:20]Br>CN(C=O)C>[F:1][C:2]1[C:9]2[O:10][CH2:19][CH2:20][O:11][C:8]=2[CH:7]=[C:4]([CH:5]=[O:6])[CH:3]=1参加物
5
実験手順
To a solution of 3-fluoro-4,5-dihydroxybenzaldehyde (0.66 g, 4.2 mmol) in DMF (30 ml) was added potassium carbonate (1.15 g, 8.3 mmol) and 1,2-dibromoethane (0.72 ml, 8.3 mmol) and the resultant mixture was heated to 80° C. for 18 h before the solvent was removed under reduced pressure. The reaction mixture was then treated with dichloromethane and water. The aqueous phase was extracted twice with dichloromethane and the combined organic phases were dried and the solvent was removed under reduced pressure to give the desired compound as a cream solid (0.73 g, 95%).
後処理
- customwas removed under reduced pressure
- additionThe reaction mixture was then treated with dichloromethane and water
- extractionThe aqueous phase was extracted twice with dichloromethane
- customthe combined organic phases were dried
- customthe solvent was removed under reduced pressure
出典と根拠
- ORDレコード
- ord-ae2de73b0a5c4c679f9b21e0b468d267
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07732461B2
関連ノート
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