4-(2,2,2-Trifluoro-1-hydroxyethyl)phenol → 4-(1-Hydroxy-2,2,2-trifluoroethyl)cyclohexanol
反応式
[H][H].[OH:3][CH:4]([C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=1)[C:5]([F:8])([F:7])[F:6]>C(O)(C)C.[Rh]>[OH:3][CH:4]([CH:9]1[CH2:14][CH2:13][CH:12]([OH:15])[CH2:11][CH2:10]1)[C:5]([F:6])([F:7])[F:8]参加物
5
実験手順
At 50° C. and a hydrogen pressure of 150 bar, 44.1 g of 4-(1-hydroxy-2,2,2-trifluoroethyl)phenol were hydrogenated in the presence of 3 g of rhodium (5% on carbon) in 500 ml of isopropanol. The catalyst was filtered off and the mixture was concentrated, to give the title product as a colourless oil.
後処理
- customAt 50° C.
- filtrationThe catalyst was filtered off
- concentrationthe mixture was concentrated
出典と根拠
- ORDレコード
- ord-45ef1fa7ac7e413a9fd67f9f07bc3831
- 出典データセット
- uspto-grants-2001_03
- 特許番号
- US06197729B1
反応ノート
読み込み中…