Water → HCID 178436813、化合物

HRID 1530823ノート

反応式

HRID 1530823 の反応式
Cl[C:2]1[CH:7]=[C:6]([CH2:8][CH3:9])[N:5]=[CH:4][N:3]=1.[C:10]([C@@H:14]1[CH2:19][CH2:18][C@H:17]([NH2:20])[CH2:16][CH2:15]1)([CH3:13])([CH3:12])[CH3:11].C(N(CC)CC)C.O>C1(C)C=CC=CC=1>[C:10]([C@@H:14]1[CH2:15][CH2:16][C@H:17]([NH:20][C:2]2[CH:7]=[C:6]([CH2:8][CH3:9])[N:5]=[CH:4][N:3]=2)[CH2:18][CH2:19]1)([CH3:13])([CH3:11])[CH3:12]

参加物

6

反応物 4

HCID 962WaterHCID 8471TriethylamineHCID 111372714-Chloro-6-ethylpyrimidineHCID 178445676HCID 178445676、化合物

生成物 1

HCID 178436813HCID 178436813、化合物

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

14.3 g of 4-chloro-6-ethylpyrimidine and 17.1 g of cis-4-tert-butylcyclohexylamine were heated to 80 to 90° C. with 15.2 g of triethylamine in 75 ml of toluene for 8 hours. After cooling, the mixture was stirred with water and the organic phase was dried and concentrated. For purification, the mixture was chromatographed over silica gel (ethyl acetate). This gave the title product as a colourless oil.

後処理

  1. temperatureAfter cooling
  2. customthe organic phase was dried
  3. concentrationconcentrated
  4. customFor purification
  5. customthe mixture was chromatographed over silica gel (ethyl acetate)

出典と根拠

ORDレコード
ord-2905251673194719822e9a5f03e8a155
出典データセット
uspto-grants-2001_03
特許番号
US06197729B1

反応ノート

読み込み中…