Pyrrole-2-carboxaldehyde → (Z)-1,3-Dihydro-4-fluoro-5-nitro-3-[(1H-pyrrol-2-yl)methylene]-2H-indol-2-one

HRID 1531151ノート

反応式

HRID 1531151 の反応式
[F:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][C:5](=[O:14])[NH:6]2.[NH:15]1[CH:19]=[CH:18][CH:17]=[C:16]1[CH:20]=O.[OH-].C([N+](CCCC)(CCCC)CCCC)CCC>CO>[F:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][CH:8]=[C:7]2[C:3]=1/[C:4](=[CH:20]/[C:16]1[NH:15][CH:19]=[CH:18][CH:17]=1)/[C:5](=[O:14])[NH:6]2

参加物

5

反応物 3

HCID 13854Pyrrole-2-carboxaldehydeHCID 2723671Tetrabutylammonium HydroxideHCID 155126004-Fluoro-5-nitroindolin-2-one2 回

生成物 1

HCID 21253427(Z)-1,3-Dihydro-4-fluoro-5-nitro-3-[(1H-pyrrol-2-yl)methylene]-2H-indol-2-one

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 1,3-dihydro-4-fluoro-5-nitro-2H-indol-2-one (400 mg, 2.04 mmol) (Starting Material 10) in MeOH (4 mL), was successively added at room temperature pyrrole-2-carboxaldehyde (220 mg, 2.25 mmol) (Aldrich) and tetrabutyl ammonium hydroxide (4.5 mL, 1.0 M solution in MeOH)(Aldrich). The mixture was stirred at r.t. for 12 h, then quenched with 1N HCl. The yellow precipitate was collected by suction filtration, washed with water and dried in a vacuum oven. (Yield 510 mg, 92%).

後処理

  1. customquenched with 1N HCl
  2. filtrationThe yellow precipitate was collected by suction filtration
  3. washwashed with water
  4. customdried in a vacuum oven

出典と根拠

ORDレコード
ord-3c4d87cdfe27459487a37b92a311bb7d
出典データセット
uspto-grants-2001_03
特許番号
US06197804B1

反応ノート

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