Indan-5-amine → N-(Indan-5-yl)-2-(4-trifluoromethyl-phenyl)-nicotinamide hydrochloride
反応式
C1(S(N[CH:11]2[CH2:19][C:18]3[C:13](=[CH:14][CH:15]=[C:16]([NH:20][C:21]([C:23]4[C:24]([C:29]5[CH:34]=[CH:33][C:32]([C:35]([F:38])([F:37])[F:36])=[CH:31][CH:30]=5)=C[CH:26]=[CH:27][CH:28]=4)=[O:22])[CH:17]=3)[CH2:12]2)(=O)=O)C=CC=CC=1.FC(F)(F)C1C=CC(C2[N:55]=CC=CC=2C([Cl:51])=O)=CC=1.NC1C=C2C(=CC=1)CCC2>>[ClH:51].[CH2:12]1[C:13]2[C:18](=[CH:17][C:16]([NH:20][C:21](=[O:22])[C:23]3[CH:28]=[CH:27][CH:26]=[N:55][C:24]=3[C:29]3[CH:34]=[CH:33][C:32]([C:35]([F:38])([F:36])[F:37])=[CH:31][CH:30]=3)=[CH:15][CH:14]=2)[CH2:19][CH2:11]1参加物
4
実験手順
The title compound is prepared in a manner similar to that described for the title E compound of Example 1 using 2-(4-trifluoromethyl-phenyl)-nicotinoyl chloride (2.228 mmol) and 5-aminoindan (0.296 g, 2.228 mmol) to give the product as the free base. The hydrochloride salt is prepared by bubbling HCl(g) through an ethyl acetate solution of the free base and trituation of the salt with diethyl ether; mp 190-205° C. MS (ES+) m/z 383 (M+1).