1-Methoxy-2-propanol → HCID 21253722、化合物
反応式
Cl[CH2:2][C:3]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([N+:14]([O-:16])=[O:15])[CH:9]=2)[O:5][N:4]=1.[SH:17]C(O)C.C(N(CC)CC)C.C[O:29][CH2:30][CH:31](O)C>>[OH:29][CH2:30][CH2:31][S:17][CH2:2][C:3]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([N+:14]([O-:16])=[O:15])[CH:9]=2)[O:5][N:4]=1参加物
5
反応条件
- 温度
- 100 °C
実験手順
A mixture of 132 g (0.55 mmol) of 3-chloromethyl-5-(3′-nitrophenyl)-1,2,4-oxadiazole (obtainable by reaction of 3-nitrobenzoyl chloride with chloroacetamide oxime), 39.0 ml (0.56 mol) of mercaptoethanol and 80 ml of triethylamine in 700 ml of 1-methoxy-2-propanol was heated to 100° C. for 4 h and, after cooling down, poured onto ice-water. The precipitated solid was filtered off with suction, washed with water and dried at 40° C. under reduced pressure. 142 g of the compound of the formula