1H-1,2,4-Triazole → HCID 3823094、化合物

A solution of chloromethyl ethyl ether (23.5 g) in toluene (300 ml ), was added dropwise, over an hour, to a solution of 1,2,4-triazole (50 g) in toluene (50 ml), and the reaction stirred at room temperature for 18 hours. On cooling, the reaction mixture was evaporated to dryness in vacuo, the residue triturated with dichloromethane, and the resulting suspension filtered. The filtrate was evaporated in vacuo and purified by column chromatography over silica gel (5/95 methanol/dichloromethane) to afford the title compound as a colorless oil, 23.9 g.

1. temperatureOn cooling
2. customthe reaction mixture was evaporated to dryness in vacuo
3. customthe residue triturated with dichloromethane
4. filtrationthe resulting suspension filtered
5. customThe filtrate was evaporated in vacuo
6. custompurified by column chromatography over silica gel (5/95 methanol/dichloromethane)

ORDレコード

ord-67d82656fc0e497ebabe9202c04b881d

出典データセット

uspto-grants-2001_03

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US06200978B1