Sodium Methoxide → 13870-70-7

HRID 1531841ノート

反応式

HRID 1531841 の反応式
C[O-].[Na+].[C:4]1([NH:10][C:11]([NH:13][CH2:14][C:15]#[CH:16])=[O:12])[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>C1(C)C=CC=CC=1>[CH3:16][C:15]1[N:10]([C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=2)[C:11](=[O:12])[NH:13][CH:14]=1

参加物

4

反応物 2

HCID 10942334Sodium MethoxideHCID 14344959N-Phenyl-N'-prop-2-yn-1-ylurea

生成物 1

HCID 1541080813870-70-7収率 55.6%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

0.8 ml of 5.35 N sodium methoxide is added to a suspension of 10 g (0.062 mol) of N-phenyl-N′-propargylurea in 140 ml of toluene. The mixture is heated at the reflux temperature for 4 hours. The solvent is evaporated and then the solid residue is taken up in acetone. The product precipitates, it is filtered, washed with a small amount of acetone and dried under vacuum at 50° C. 6 g of product are obtained. (m.p.=207° C.).

後処理

  1. temperatureThe mixture is heated at the reflux temperature for 4 hours
  2. customThe solvent is evaporated
  3. customThe product precipitates
  4. filtrationit is filtered
  5. washwashed with a small amount of acetone
  6. customdried under vacuum at 50° C

出典と根拠

ORDレコード
ord-fc92d63812924b6994978de364c15c7a
出典データセット
uspto-grants-2001_03
特許番号
US06200991B1

反応ノート

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