Potassium Iodide → Methyl 4-methoxy-2-propoxybenzoate

HRID 1532084

反応式

HRID 1532084 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([OH:13])[C:6](=[CH:11][CH:12]=1)[C:7]([O:9][CH3:10])=[O:8].Br[CH2:15][CH2:16][CH3:17].[I-].[K+].C(=O)([O-])[O-].[K+].[K+]>C(OCC)C>[CH3:10][O:9][C:7](=[O:8])[C:6]1[CH:11]=[CH:12][C:3]([O:2][CH3:1])=[CH:4][C:5]=1[O:13][CH2:15][CH2:16][CH3:17]

参加物

6

反応物 4

HCID 4875Potassium IodideHCID 78401-BromopropaneHCID 11430Potassium CarbonateHCID 79523Methyl 4-methoxysalicylate

生成物 1

HCID 21250797Methyl 4-methoxy-2-propoxybenzoate

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

A stirred mixture of methyl 4-methoxysalicylate (25 g), bromopropane (15.6 ml), potassium iodide (2.82 g) and anhydrous potassium carbonate (27.53 g) was heated under reflux for 48 hours. The cooled reaction mixture was filtered and the filtrate was evaporated under reduced pressure to yield an oil which was dissolved in diethyl ether (200 ml). The ethereal solution was extracted with aqueous sodium hydroxide to remove unreacted starting material and the organic phase was then washed with water and brine, dried (magnesium sulphate) and evaporated under reduced pressure to yield methyl4-methoxy-2-propoxy-benzoate, 22.45 g.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 48 hours
  3. customThe cooled reaction mixture
  4. filtrationwas filtered
  5. customthe filtrate was evaporated under reduced pressure
  6. customto yield an oil which
  7. extractionThe ethereal solution was extracted with aqueous sodium hydroxide
  8. customto remove unreacted
  9. washthe organic phase was then washed with water and brine
  10. dry with materialdried (magnesium sulphate)
  11. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-265fb716a3ca4235aaab0e0bb98f4e85
出典データセット
uspto-grants-2001_03
特許番号
US06200980B1

関連ノート

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