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Pyrrolidine → 4-[4-(4,4'-Dipentylbicyclohexyl-4-ylethynyl)-3-fluorophenylethynyl]-4-methoxy-4'-propyl-bicyclohexyl
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyrrolidine | HCID 31268 | — |
| 反応物 | 4-Ethynyl-4-methoxy-4'-propylbicyclohexyl | HCID 18364508 | — |
| 反応物 | 4-(4-Bromo-2-fluorophenylethynyl)-4,4'-dipentylbicyclohexyl | HCID 22013388 | — |
| 触媒 | HCID 178418397 | HCID 178418397 | — |
| 生成物 | 4-[4-(4,4'-Dipentylbicyclohexyl-4-ylethynyl)-3-fluorophenylethynyl]-4-methoxy-4'-propyl-bicyclohexyl | HCID 22013390 | — |
反応手順
Analogously to Example 4, 1.913 g of 4-(4-bromo-2-fluorophenylethynyl)-4,4′-dipentylbicyclohexyl are reacted with 0.997 g of 4-ethynyl-4-methoxy-4′-propylbicyclohexyl in the presence of 0.219 g of tetrakis(triphenylphosphine)palladium(0) and 5 ml of pyrrolidine, giving 4-[4-(4,4′-dipentylbicyclohexyl-4-ylethynyl)-3-fluorophenylethynyl]-4-methoxy-4′-propyl-bicyclohexyl (C 177 N (36) I, Δε −0.26, Δn −0.015).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06203724B1 |
| 出典データセット | uspto-grants-2001_03 |
| ORD ID | ord-0950396a12044c6da6857bf0ebd79153 |
| 出典メモ | uspto-grants-2001_03 |