2,5-Dichlorotoluene → Methyl 5-(2,5-Dichlorophenyl)pentanoate

反応式

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[CH3:9].[CH3:10][O:11][C:12](OC)([O:17]C)[CH2:13][CH2:14][CH2:15]Br>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[CH2:9][CH2:15][CH2:14][CH2:13][C:12]([O:11][CH3:10])=[O:17]

参加物

反応物 2

HCID 295722,5-Dichlorotoluene

HCID 5187924Trimethyl 4-bromoorthobutyrate

生成物 1

HCID 22013526Methyl 5-(2,5-Dichlorophenyl)pentanoate

実験手順

The anion of 2,5-dichlorotoluene was reacted with trimethyl 4-bromoorthobutyrate to produce methyl 5-(2,5-dichlorophenyl)pentanoate after mild hydrolytic work-up. Competitor A was prepared by LiOH hydrolysis of the methyl ester.

出典と根拠

ORDレコード: ord-7c48853ae45648088bc8b6f7a29ad439
出典データセット: uspto-grants-2001_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06204005B1

反応ノート

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