Alpha-Cyclodextrin → (+)-Lactose

HRID 1532584ノート

反応式

HRID 1532584 の反応式
C([O-])(=O)C(CCC)CCC.[Na+].[CH2:12]([OH:77])[C@H:13]1[O:18][C@@H:17]2[O:19][C@H:20]3[C@H:25]([OH:26])[C@@H:24]([OH:27])[C@@H:23]([O:28][C@H:29]4[C@H:34]([OH:35])[C@@H:33]([OH:36])[C@@H:32]([O:37][C@H:38]5[C@H:43]([OH:44])[C@@H:42]([OH:45])[C@@H:41]([O:46][C@H:47]6[C@H:52]([OH:53])[C@@H:51]([OH:54])[C@@H:50]([O:55][C@H:56]7[C@H:62]([OH:63])[C@@H:61]([OH:64])[C@@H:59]([O:60][C@H:14]1[C@H:15]([OH:76])[C@H:16]2[OH:75])[O:58][C@@H:57]7[CH2:65][OH:66])[O:49][C@@H:48]6[CH2:67][OH:68])[O:40][C@@H:39]5[CH2:69][OH:70])[O:31][C@@H:30]4[CH2:71][OH:72])[O:22][C@@H:21]3[CH2:73][OH:74]>O>[OH:19][CH:17]1[O:18][C@H:13]([CH2:12][OH:77])[C@@H:14]([O:60][C@@H:59]2[O:58][C@H:57]([CH2:65][OH:66])[C@H:56]([OH:55])[C@H:62]([OH:63])[C@H:61]2[OH:64])[C@H:15]([OH:76])[C@H:16]1[OH:75].[CH2:67]([OH:68])[C@H:48]1[O:49][C@@H:50]2[O:55][C@H:56]3[C@H:62]([OH:63])[C@@H:61]([OH:64])[C@@H:59]([O:60][C@H:14]4[C@H:15]([OH:76])[C@@H:16]([OH:75])[C@@H:17]([O:19][C@H:20]5[C@H:25]([OH:26])[C@@H:24]([OH:27])[C@@H:23]([O:28][C@H:29]6[C@H:34]([OH:35])[C@@H:33]([OH:36])[C@@H:32]([O:37][C@H:38]7[C@H:43]([OH:44])[C@@H:42]([OH:45])[C@@H:41]([O:46][C@H:47]1[C@H:52]([OH:53])[C@H:51]2[OH:54])[O:40][C@@H:39]7[CH2:69][OH:70])[O:31][C@@H:30]6[CH2:71][OH:72])[O:22][C@@H:21]5[CH2:73][OH:74])[O:18][C@@H:13]4[CH2:12][OH:77])[O:58][C@@H:57]3[CH2:65][OH:66]

参加物

5

反応物 2

HCID 444913Alpha-CyclodextrinHCID 16760703Sodium valproate

生成物 2

HCID 440995(+)-LactoseHCID 444913Alpha-Cyclodextrin

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

166 g (1 mole) sodium valproate and 90 g (moisture content<5%, 0.09 mole) a α-cyclodextrin are blended and 20 mL water is added. The ingredients are thoroughly kneaded, and the product is obtained by drying and grinding as described in Example 1. The moisture absorption after 24 hour storage at 40° C. under 75% relative humidity was found to be 43%, compared to 70% and 47% of sodium valproate itself and of the product obtained in a similar way with lactose instead of a α-cyclodextrin, respectively. The latter two were liquified.

後処理

  1. customthe product is obtained
  2. customby drying
  3. customgrinding
  4. customThe moisture absorption after 24 hour storage at 40° C. under 75% relative humidity

出典と根拠

ORDレコード
ord-6f30f466fc1f4d8ea80dd3343d197fba
出典データセット
uspto-grants-2001_03
特許番号
US06204255B1

反応ノート

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