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(-)-Asparagine → N-Phenysulfonyl-L-asparagine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (-)-Asparagine | HCID 6267 | — |
| 反応物 | Benzenesulfonyl chloride | HCID 7369 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | N-Phenysulfonyl-L-asparagine | HCID 10754635 | — |
反応手順
To L-Asparagine (10 g), add sodium hydroxide (3.4 g) and dioxane/water (50 mL/50 mL). Cool resulting solution in an ice bath and add benzenesulfonyl chloride (10.6 mL), sodium hydroxide (3.4 g), and water (80 mL). Stir for 3 hours. Add water (200 mL) and extract with EtOAc. Acidify the aqueous solution to pH 3 with concentrated HCl and cool to give a precipitate. After 1 hour collect the solid and dry it in vacuo at 40° C. to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06204282B1 |
| 出典データセット | uspto-grants-2001_03 |
| ORD ID | ord-afbdb89e85ab49899ea1c627af485223 |
| 出典メモ | uspto-grants-2001_03 |