N,N-Dimethyl-1,3-propanediamine → HCID 22013769、化合物

HRID 1532657ノート

反応式

HRID 1532657 の反応式
[CH3:1][N:2]([CH3:7])[CH2:3][CH2:4][CH2:5][NH2:6].Cl[C:9]1[CH:19]=[CH:18][C:12]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:11][C:10]=1[N+:20]([O-:22])=[O:21]>C(OCC)(=O)C>[CH3:1][N:2]([CH3:7])[CH2:3][CH2:4][CH2:5][NH:6][C:9]1[CH:19]=[CH:18][C:12]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:11][C:10]=1[N+:20]([O-:22])=[O:21]

参加物

4

反応物 2

HCID 7993N,N-Dimethyl-1,3-propanediamineHCID 1268247Ethyl 4-chloro-3-nitrobenzoate

生成物 1

HCID 22013769HCID 22013769、化合物収率 101.2%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

反応条件

温度
125 °C

実験手順

N,N-Dimethy-1,3-propanediamine (1.41 g) was added to ethyl 4-chloro-3-nitrobenzoate (1.59 g) and stirred for 12 hours at 125° C. The reaction mixture, with ethyl acetate added thereto, was washed with 1N sodium hydroxide aqueous solution, water, and saturated brine successively, dried over sodium sulfate anhydride, and concentrated, thereby yielding the entitled compound (2.07 g) as brown oil.

後処理

  1. washwas washed with 1N sodium hydroxide aqueous solution, water, and saturated brine successively
  2. dry with materialdried over sodium sulfate anhydride
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-1f6d9195e4494539b03d21d4b032ff02
出典データセット
uspto-grants-2001_03
特許番号
US06204264B1

反応ノート

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