HCID 22013769、化合物 → Ethyl 3-amino-4-[[3-(dimethylamino)propyl]amino]benzoate

HRID 1532658ノート

反応式

HRID 1532658 の反応式
[CH3:1][N:2]([CH3:21])[CH2:3][CH2:4][CH2:5][NH:6][C:7]1[CH:17]=[CH:16][C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:9][C:8]=1[N+:18]([O-])=O>C(O)C.[C].[Pd]>[NH2:18][C:8]1[CH:9]=[C:10]([CH:16]=[CH:17][C:7]=1[NH:6][CH2:5][CH2:4][CH2:3][N:2]([CH3:21])[CH3:1])[C:11]([O:13][CH2:14][CH3:15])=[O:12]

参加物

4

反応物 1

HCID 22013769HCID 22013769、化合物

生成物 1

HCID 22013774Ethyl 3-amino-4-[[3-(dimethylamino)propyl]amino]benzoate収率 101.9%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 702Ethanol溶媒

実験手順

10% of palladium-carbon (0.40 g) was added to a solution containing ethyl 4-{[3-(dimethylamino)propyl]amino}-3-nitrobenzoate (2.02 g) in ethanol (20 ml) and stirred for 5 hours under a hydrogen gas atmosphere at room temperature. After the catalyst was removed out by filtration, the filtrate was concentrated, thereby yielding the entitled compound (1.85 g) as dark red oil.

後処理

  1. customAfter the catalyst was removed out by filtration
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-cedc4bdd46bf4da08a0a95c3a88e3aad
出典データセット
uspto-grants-2001_03
特許番号
US06204264B1

反応ノート

読み込み中…