Ethanol → HCID 9915090、化合物

反応式

[ClH:1].C(OCC)(=O)C.[CH3:8][N:9]([CH3:43])[CH2:10][CH2:11][CH2:12][NH:13][C:14]([C:16]1[N:20]([CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH3:38])[C:19]2[CH:39]=[CH:40][CH:41]=[CH:42][C:18]=2[N:17]=1)=[O:15].C(O)C>C(OCC)(=O)C>[ClH:1].[CH3:43][N:9]([CH3:8])[CH2:10][CH2:11][CH2:12][NH:13][C:14]([C:16]1[N:20]([CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH3:38])[C:19]2[CH:39]=[CH:40][CH:41]=[CH:42][C:18]=2[N:17]=1)=[O:15]

参加物

実験手順

4N Hydrochloric acid/ethyl acetate solution (0.25 ml) was added to a solution containing N-[3-(dimethylamino)propyl]-1-octadecyl-1H-benzimidazole-2-carboxamide (0.499 g) in ethyl acetate (5 ml) and stirred for 10 minutes at room temperature. The reaction mixture, with ethanol (0.3 ml) and ethyl acetate (1 ml) added thereto, was dissolved by heating and then cooled naturally. The depositing crystals were collected by filtration, thereby yielding the entitled compound (0.419 g) as white solid.