Hydrogen chloride-ethyl acetate → HCID 22013762、化合物

HRID 1532688ノート

反応式

HRID 1532688 の反応式
[ClH:1].C(OCC)(=O)C.[CH3:8][N:9]([CH3:47])[CH2:10][CH2:11][CH2:12][N:13]1[C:17]2[CH:18]=[CH:19][C:20]([C:22]([NH:24][CH3:25])=[O:23])=[CH:21][C:16]=2[N:15]=[C:14]1[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH3:46]>C(OCC)(=O)C.C(O)C>[ClH:1].[CH3:47][N:9]([CH3:8])[CH2:10][CH2:11][CH2:12][N:13]1[C:17]2[CH:18]=[CH:19][C:20]([C:22]([NH:24][CH3:25])=[O:23])=[CH:21][C:16]=2[N:15]=[C:14]1[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH3:46]

参加物

5

反応物 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 22013763HCID 22013763、化合物

生成物 1

HCID 22013762HCID 22013762、化合物

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

4N Hydrochloric acid/ethyl acetate solution (0.89 ml) was added to a solution containing 1-[3-(dimethylamino)propyl]-2-henicosyl-N-methyl-1H-benzimidazole-5-carboxamide (1.818 g) in a mixture of ethyl acetate (18 ml) and ethanol (1.8 ml). After being stirred for 30 minutes at room temperature, the reaction mixture was concentrated. The residue was recrystallized with the mixed solution of ethyl acetate-ethanol, thereby yielding the entitled compound (1.611 g) as white crystals.

後処理

  1. concentrationthe reaction mixture was concentrated
  2. customThe residue was recrystallized with the mixed solution of ethyl acetate-ethanol

出典と根拠

ORDレコード
ord-7c4bd62862fc49ad97d6b1d408b68261
出典データセット
uspto-grants-2001_03
特許番号
US06204264B1

反応ノート

読み込み中…