Hydrogen chloride-ethyl acetate → HCID 22013777、化合物

HRID 1532692ノート

反応式

HRID 1532692 の反応式
[ClH:1].C(OCC)(=O)C.[CH3:8][N:9]([CH3:42])[CH2:10][CH2:11][N:12]1[C:16]2[CH:17]=[CH:18][C:19]([C:21]([NH:23][CH3:24])=[O:22])=[CH:20][C:15]=2[N:14]=[C:13]1[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH3:41]>C(OCC)(=O)C.C(O)C>[ClH:1].[CH3:8][N:9]([CH3:42])[CH2:10][CH2:11][N:12]1[C:16]2[CH:17]=[CH:18][C:19]([C:21]([NH:23][CH3:24])=[O:22])=[CH:20][C:15]=2[N:14]=[C:13]1[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH3:41]

参加物

5

反応物 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 22013765HCID 22013765、化合物

生成物 1

HCID 22013777HCID 22013777、化合物

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

4N Hydrochloric acid/ethyl acetate solution (1.24 ml) was added to a solution containing 1-[2-(dimethylamino)ethyl]-2-heptadecyl-N-methyl-1H-benzimidazole-5-carboxamide (2.207 g) in a mixture of ethyl acetate (22 ml) and ethanol (2 ml). After being stirred for 30 minutes while being cooled with ice, the reaction mixture was concentrated. The residue was recrystallized with the mixed solution of ethyl acetate-ethanol, thereby yielding the entitled compound (1.751 g) as white crystals.

後処理

  1. temperaturewhile being cooled with ice
  2. concentrationthe reaction mixture was concentrated
  3. customThe residue was recrystallized with the mixed solution of ethyl acetate-ethanol

出典と根拠

ORDレコード
ord-fe0ea16a2d7a42b3ba1d89e5c62176fb
出典データセット
uspto-grants-2001_03
特許番号
US06204264B1

反応ノート

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