Catechol → 2-(2-Methoxyethoxy)phenol
反応式
[C:1]1([C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[OH:4])[OH:2].Br[CH2:10][CH2:11][O:12][CH3:13].C(=O)([O-])[O-].[K+].[K+]>C(O)C>[CH3:13][O:12][CH2:11][CH2:10][O:2][C:1]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[OH:4]参加物
5
実験手順
Catechol (10.0 g, 91 mmol), bromoethylmethylether (12.6 g, 91 mmol), and potassium carbonate (12.6 g, 91 mmol) were mixed in ethanol (100 ml) and refluxed for 15 h. The solvent was evaporated and dichloromethane (200 ml) was added. The inorganics were filtered off and the solvent was removed in vacuum. Chromatography on silica gel with 0.5% methanol in dichloromethane as the eluent gave the title compound. Yield 4.5 g, 29%.
後処理
- temperaturerefluxed for 15 h
- customThe solvent was evaporated
- additiondichloromethane (200 ml) was added
- filtrationThe inorganics were filtered off
- customthe solvent was removed in vacuum
出典と根拠
- ORDレコード
- ord-98c7a295955b4ec39756183a3eac6515
- 出典データセット
- uspto-grants-2001_03
- 特許番号
- US06207662B1
反応ノート
読み込み中…