Hydrochloric Acid → Methyl (1,2-benzoxazol-3-yl)acetate

HRID 1533013

反応式

HRID 1533013 の反応式
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH2:10][C:11]([OH:13])=[O:12])=[N:2]1.[CH3:14]COCC.Cl>CO>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH2:10][C:11]([O:13][CH3:14])=[O:12])=[N:2]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 3017292-(1,2-Benzoxazol-3-yl)acetic acid

生成物 1

HCID 2763403Methyl (1,2-benzoxazol-3-yl)acetate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of 1,2-benzisoxazole-3-acetic acid (prepared according to G. Casini et al, J. Het. Chem. 6, 1969, 279) (18 g), ether saturated with dry HCl (150 ml) and methanol (200 ml) was stirred for 2 h at room temperature. Removal of the volatiles in vacuo gave methyl 1 ,2-benzisoxazole-3-acetate (17 g) as an oil. The oil was dissolved in tetrahydrofuran (100 ml) and added dropwise to a suspension of lithium aluminium hydride (6 g) in tetrahydrofuran (200 ml) at 0-10° C. followed by stirring for 30 min at 15° C. Usual work-up gave 2-(1 ,2-benzisoxazol-3-yl)ethanol (13 g) as an oil.

後処理

  1. customRemoval of the volatiles in vacuo

出典と根拠

ORDレコード
ord-d617c80cd00c42ca844004d2d4805f0a
出典データセット
uspto-grants-2001_03
特許番号
US06207677B1

関連ノート

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