3-Pyridylmethyl isothiocyanate → HCID 22707701、化合物

反応式

[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[CH3:13])[N:9]=[CH:8][N:7]=[C:6]2[N:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1.[N:20]1[CH:25]=[CH:24][CH:23]=[C:22]([CH2:26][N:27]=[C:28]=[S:29])[CH:21]=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[CH3:13])[N:9]=[CH:8][N:7]=[C:6]2[N:14]1[CH2:15][CH2:16][N:17]([C:28](=[S:29])[NH:27][CH2:26][C:22]2[CH:21]=[N:20][CH:25]=[CH:24][CH:23]=2)[CH2:18][CH2:19]1

参加物

反応物 2

HCID 27604203-Pyridylmethyl isothiocyanate

HCID 22707665HCID 22707665、化合物

生成物 1

HCID 22707701HCID 22707701、化合物収率 36%

実験手順

Substantially the same procedure as in Example 1 was repeated, except that 6-methoxy-7-methyl-4-(1-piperazinyl)quinazoline was used in place of 6,7-dimethoxy-4-(1-piperazinyl)quinazoline, and the corresponding 3-picolyl isothiocyanate was used in place of phenyl isocyanate, to give the desired compound.

出典と根拠

ORDレコード: ord-5d64642c599946babbb5de674347c0e1
出典データセット: uspto-grants-2001_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06207667B1

反応ノート

読み込み中…