2,3-Dihydrofuro[2,3-c]pyridin-5-ylmethanol → 2,3-Dihydrofuro[2,3-c]pyridine-5-carbaldehyde

HRID 15332ノート

反応式

HRID 15332 の反応式
[O:1]1[C:5]2=[CH:6][N:7]=[C:8]([CH2:10][OH:11])[CH:9]=[C:4]2[CH2:3][CH2:2]1>ClCCl.[O-2].[O-2].[Mn+4]>[O:1]1[C:5]2=[CH:6][N:7]=[C:8]([CH:10]=[O:11])[CH:9]=[C:4]2[CH2:3][CH2:2]1

参加物

4

反応物 1

HCID 574231212,3-Dihydrofuro[2,3-c]pyridin-5-ylmethanol

生成物 1

HCID 574231162,3-Dihydrofuro[2,3-c]pyridine-5-carbaldehyde収率 70%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6344Dichloromethane溶媒

実験手順

2,3-Dihydrofuro[2,3-c]pyridin-5-ylmethanol (1.31 g, 8.7 mmol) was dissolved in dichloromethane (100 ml) and treated with manganese dioxide (6 g, 69 mmol) at ambient temperature with vigorous stirring for 18 h. The mixture was filtered through kieselguhr and the filtrate evaporated to dryness to provide the desired compound (0.9 g, 70%).

後処理

  1. filtrationThe mixture was filtered through kieselguhr
  2. customthe filtrate evaporated to dryness

出典と根拠

ORDレコード
ord-6c66c9facbec48ee8f5ce4b4d05f60cc
出典データセット
uspto-grants-2010_06
特許番号
US07732461B2

反応ノート

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