Hydrogen chloride-ethyl acetate → HCID 178441760、化合物
反応式
[OH:1][CH:2]([C:16]1[N:17]=[C:18]([CH2:28][CH2:29][CH2:30][CH3:31])[N:19](C(OC(C)(C)C)=O)[CH:20]=1)[CH:3]([C:7]1[CH:12]=[CH:11][C:10]2[O:13][CH2:14][O:15][C:9]=2[CH:8]=1)[C:4]([OH:6])=[O:5].C(OCC)(=O)C.[ClH:38]>>[ClH:38].[OH:1][CH:2]([C:16]1[N:17]=[C:18]([CH2:28][CH2:29][CH2:30][CH3:31])[NH:19][CH:20]=1)[CH:3]([C:7]1[CH:12]=[CH:11][C:10]2[O:13][CH2:14][O:15][C:9]=2[CH:8]=1)[C:4]([OH:6])=[O:5]参加物
3
実験手順
A solution of (2RS,3SR)-3-hydroxy-2-(3,4-methylenedioxyphenyl)-3-(2-n-butyl-1-tert-butoxycarbonyl-1H-imidazol-4-yl)propionic acid (250 mg) in 4N hydrogen chloride-ethyl acetate solution (3 ml) was stirred at ambient temperature for 18 hours. The solution was evaporated in vacuo and then the residue was solidified with ether. Resulting powder was collected by filtration and dried to afford (2RS,3SR)-3-hydroxy-2-(3,4-methylenedioxyphenyl)-3-(2-n-butyl-1H-imidazol-4-yl)propionic acid hydrochloride (65 mg).
後処理
- customThe solution was evaporated in vacuo
- customResulting powder
- filtrationwas collected by filtration
- customdried