Sodium Nitrite → (R)-1-Phenyl-3-propanolamine
反応式
[C:1]1([C@@H:7]([CH2:11][CH2:12][OH:13])C(O)=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[N:14]([O-])=O.[Na+]>OS(O)(=O)=O>[C:1]1([C@H:7]([NH2:14])[CH2:11][CH2:12][OH:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1参加物
4
反応条件
- 温度
- 2.5 °C
実験手順
The hydrazide of (R)-2-phenyl-4-hydroxybutanoic acid (0.5 gram) is reacted with a solution of 0.5 grams of sodium nitrite in 10 ml of 5% H2SO4. The reaction mixture is maintained for 1 hour at 0-5° C., followed extraction of the reaction mixture with ethyl acetate, followed by basification of the resulting aqueous solution with NaOH, extraction with methyl t-butyl ether, drying of the extracts over MgSO4, filtration, and the removal of solvent by rotary evaporation. The product (R)-1-phenyl-3-hydroxypropylamine is isolated as a light yellow oil.
後処理
- extractionextraction of the reaction mixture with ethyl acetate
- extractionfollowed by basification of the resulting aqueous solution with NaOH, extraction with methyl t-butyl ether
- dry with materialdrying of the extracts over MgSO4, filtration
- customthe removal of solvent
- customby rotary evaporation
出典と根拠
- ORDレコード
- ord-cce517ae8137401e96e89b384c244c77
- 出典データセット
- uspto-grants-2001_03
- 特許番号
- US06207862B1
反応ノート
読み込み中…