N,N-Dimethylethylenediamine → 2-[2-(dimethylamino)ethylamino]-4-nitro-1H-benzimidazole

HRID 1533780ノート

反応式

HRID 1533780 の反応式
Cl[C:2]1[NH:6][C:5]2[CH:7]=[CH:8][CH:9]=[C:10]([N+:11]([O-:13])=[O:12])[C:4]=2[N:3]=1.[CH3:14][N:15]([CH3:19])[CH2:16][CH2:17][NH2:18].C(=O)(O)[O-].[Na+]>>[CH3:14][N:15]([CH3:19])[CH2:16][CH2:17][NH:18][C:2]1[NH:6][C:5]2[CH:7]=[CH:8][CH:9]=[C:10]([N+:11]([O-:13])=[O:12])[C:4]=2[N:3]=1

参加物

4

反応物 3

HCID 66053N,N-DimethylethylenediamineHCID 516892Sodium BicarbonateHCID 14765451HCID 14765451、化合物

生成物 1

HCID 183786772-[2-(dimethylamino)ethylamino]-4-nitro-1H-benzimidazole

反応条件

温度
80 °C

実験手順

A mixture of 2-chloro-4-nitro-1H-benzimidazole (300 mg) and N,N-dimethylethylenediamine (2 ml) were stirred at 80° C. for 8 hours. The reaction mixture was poured into saturated sodium bicarbonate aqueous solution and extracted with a mixture of chloroform and methanol. The organic layer was washed with brine, dried over magnesium sulfate and evaporated in vacuo. The residue was washed with diisopropyl ether to give 2-[[2-(dimethylamino)ethyl]amino]-4-nitro-1H-benzimidazole (113 mg).

後処理

  1. extractionextracted with a mixture of chloroform and methanol
  2. washThe organic layer was washed with brine
  3. dry with materialdried over magnesium sulfate
  4. customevaporated in vacuo
  5. washThe residue was washed with diisopropyl ether

出典と根拠

ORDレコード
ord-e6179ebf95bd4aa2a97232e4d303c645
出典データセット
uspto-grants-2001_03
特許番号
US06207693B1

反応ノート

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