Pyridinium chloride → (2-hydroxyphenyl)-(1-methyl-1H-indol-4-yl) methanone

HRID 1533991ノート

反応式

HRID 1533991 の反応式
C[O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]([C:11]1[CH:19]=[CH:18][CH:17]=[C:16]2[C:12]=1[CH:13]=[CH:14][N:15]2[CH3:20])=[O:10].Cl.N1C=CC=CC=1>C(Cl)Cl>[OH:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]([C:11]1[CH:19]=[CH:18][CH:17]=[C:16]2[C:12]=1[CH:13]=[CH:14][N:15]2[CH3:20])=[O:10]

参加物

4

反応物 2

HCID 10176127Pyridinium chlorideHCID 67854483(2-methoxyphenyl)-(1-methyl-1H-indol-4-yl) methanone

生成物 1

HCID 67854425(2-hydroxyphenyl)-(1-methyl-1H-indol-4-yl) methanone収率 60.7%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Using the procedure of Step C of Example 3, 29.9 g of the product of Step C and 300 g of pyridine hydrochloride were reacted to obtain using methylene chloride as eluant for the chromatography 17.2 g of the expected product melting at 80° C. which was used as is for the following step.

後処理

  1. customwere reacted
  2. customto obtain

出典と根拠

ORDレコード
ord-14a029a606614662ae77a4507290ca01
出典データセット
uspto-grants-1992_02
特許番号
US05086070

反応ノート

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