Ketoprofen → Ketoprofen amide

反応式

CC([NH2:9])C1C=CC=CC=1.[OH:10][C:11]([CH:13]([C:15]1[CH:28]=[CH:27][CH:26]=[C:17]([C:18]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:19])[CH:16]=1)[CH3:14])=O>>[CH3:14][CH:13]([C:11]([NH2:9])=[O:10])[C:15]1[CH:16]=[C:17]([C:18]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:19])[CH:26]=[CH:27][CH:28]=1

参加物

反応物 2

HCID 3825Ketoprofen2 回

HCID 74081-Phenethylamine

生成物 1

HCID 3042314Ketoprofen amide

実験手順

The basic phase is acidified and is then extracted with chloroform. After forming the R (+) α-methylbenzylamine derivative of ketoprofen, analysis of the mixture of the two diastereoisomers by high performance liquid chromatography shows that the enantiomeric excess of S (+) ketoprofen is 93%.

後処理

extractionis then extracted with chloroform
customAfter forming

出典と根拠

ORDレコード: ord-94d29c0d80394f228f106d320bfd2269
出典データセット: uspto-grants-1992_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05089405

反応ノート

読み込み中…

参加物