化工社化工社 化学情報印刷レポート · 研究参考用
2-(Benzoyloxymethyl)phenylaminoacrylate → 4-Hydroxyquinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(Benzoyloxymethyl)phenylaminoacrylate | HCID 86745485 | — |
| 溶媒 | Diphenyl Ether | HCID 7583 | — |
| 生成物 | 4-Hydroxyquinoline | HCID 69141 | 110.6% |
反応手順
Diphenyl ether (500 ml) was heated to reflux, ethyl 2-isobutyryl-3-(2-(benzoyloxymethyl)phenylaminoacrylate (29.3 g, 74.1 mmol) added, and heating continued for 15 minutes. The bulk of the diphenyl ether was removed by vacuum distillation, and the residue chromatographed (silica gal, 1%-2.5% methanol in dichloromethane) and recrystallized from ethyl acetate to give 3-isobutyryl-8-benzoyloxymethyl)-4(1H)-quinolone (11.9 g, 46%), m.p. 158°-160°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05089504 |
| 出典データセット | uspto-grants-1992_02 |
| ORD ID | ord-36dd0607720a449fa5bd347b95783b9a |
| 出典メモ | uspto-grants-1992_02 |