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[1,3]Oxathiolo[5,4-c]pyridine-6-carbaldehyde → 4-({4-[([1,3]oxathiolo[5,4-c]pyridin-6-ylmethyl)amino]-1-piperidinyl}methyl)-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | [1,3]Oxathiolo[5,4-c]pyridine-6-carbaldehyde | HCID 59254367 | — |
| 反応物 | 4-[(4-Amino-1-piperidinyl)methyl]-4,5-dihydro-7h-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one dihydrochloride salt | HCID 68685371 | — |
| 生成物 | 4-({4-[([1,3]oxathiolo[5,4-c]pyridin-6-ylmethyl)amino]-1-piperidinyl}methyl)-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one hydrochloride | HCID 68688399 | — |
反応手順
The free base of the title compound was synthesised from 4-[(4-amino-1-piperidinyl)methyl]-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one dihydrochloride salt and [1,3]oxathiolo[5,4-c]pyridine-6-carbaldehyde (for a synthesis see WO2004058144, Example 61) according to the general method of Example 2(h).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07732461B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-4a0006bc761c4184b305e3d17ebbb089 |
| 出典メモ | uspto-grants-2010_06 |