4-Methoxybenzenesulfonyl chloride → 1'-(4-Methoxyphenyl)sulfonylspiro[indene-1,4'-piperidine]

反応式

[NH:1]1[CH2:6][CH2:5][C:4]2([C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[CH:8]=[CH:7]2)[CH2:3][CH2:2]1.[CH3:15][O:16][C:17]1[CH:22]=[CH:21][C:20]([S:23](Cl)(=[O:25])=[O:24])=[CH:19][CH:18]=1>>[CH3:15][O:16][C:17]1[CH:18]=[CH:19][C:20]([S:23]([N:1]2[CH2:6][CH2:5][C:4]3([C:14]4[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=4)[CH:8]=[CH:7]3)[CH2:3][CH2:2]2)(=[O:25])=[O:24])=[CH:21][CH:22]=1

参加物

反応物 2

HCID 74014-Methoxybenzenesulfonyl chloride

HCID 10330052Spiro[indene-1,4'-piperidine]

生成物 1

HCID 100211111'-(4-Methoxyphenyl)sulfonylspiro[indene-1,4'-piperidine]

実験手順

The procedure of example 3 was carried out using 20 mg (0.108 mmol) of spiro(1H-indene-1,4'-piperidine), and substituting p-methoxybenzenesulfonyl chloride (21 mg, 0.1 mmol) for the p-bromo derivative. The title compound was obtained as a solid: (m.p. 181°-183°).

出典と根拠

ORDレコード: ord-dde0e522d7a54004975937ea0f9b6433
出典データセット: uspto-grants-1992_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05091387

反応ノート

読み込み中…