化工社化工社 化学情報印刷レポート · 研究参考用
Benzenesulfonic Acid → Clopidogrel Besylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzenesulfonic Acid | HCID 7371 | — |
| 反応物 | Clopidogrel | HCID 60606 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Clopidogrel Besylate | HCID 9847991 | — |
反応手順
Clopidogrel base was dissolved in methanol to obtain a clear solution. Benzenesulfonic acid was added to the solution at 20° C. The reaction mixture was heated to reflux temperature for 2 to 10 hrs. The solvent was evaporated to dryness under reduced pressure to obtain the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07732608B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-6048977fc62747ef9066cb73c267c532 |
| 出典メモ | uspto-grants-2010_06 |