Dichloromethane → 5-Amino-1-(4-bromo-2-fluoro-phenyl)-6,7-difluoro-4-hydroxy-1,3-dihydro-benzoimidazol-2-one

反応式

[B:24]([Br:25])([Br:26])[Br:27].[Cl:50][CH2:51][Cl:52].[NH2:1][c:2]1[c:3]([O:22][CH3:23])[c:4]2[c:5]([n:6](-[c:10]3[c:11]([F:17])[cH:12][c:13]([Br:16])[cH:14][cH:15]3)[c:7](=[O:9])[nH:8]2)[c:18]([F:21])[c:19]1[F:20].[NH2:28][c:29]1[c:30]([F:31])[c:32]([F:33])[c:34]2[n:35](-[c:36]3[cH:37][cH:38][c:39]([I:40])[cH:41][c:42]3[F:43])[c:44](=[O:45])[nH:46][c:47]2[c:48]1[OH:49]>>[NH2:1][c:2]1[c:3]([OH:22])[c:4]2[c:5]([n:6](-[c:10]3[c:11]([F:17])[cH:12][c:13]([Br:16])[cH:14][cH:15]3)[c:7](=[O:9])[nH:8]2)[c:18]([F:21])[c:19]1[F:20]