化工社化工社 化学情報印刷レポート · 研究参考用
Methyl Thioglycolate → Methyl 6-fluorobenzo[b]thiophene-2-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl Thioglycolate | HCID 16907 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 2,4-Difluorobenzaldehyde | HCID 73770 | — |
| 生成物 | Methyl 6-fluorobenzo[b]thiophene-2-carboxylate | HCID 57350889 | 67.3% |
反応手順
Using 2.00 g (14.07 mmol) of 2,4-difluorobenzaldehyde, 0.84 g (21.11 mmol) of sodium hydride (60% pure) and 1.64 g (15.48 mmol) of methyl mercaptoacetate, 1.99 g of the desired product are obtained. The product is obtained in a purity which permits further reaction and is reacted without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07732477B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-b5268a2b132a40b98235200a92d6471e |
| 出典メモ | uspto-grants-2010_06 |