Methyl 3-aminothieno(2,3-b)pyridine-2-carboxylate → Methyl thieno[2,3-b]pyridine-2-carboxylate
反応式
N[C:2]1[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[S:4][C:3]=1[C:11]([O:13][CH3:14])=[O:12].N([O-])=O.[Na+]>>[S:4]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:10]2[CH:2]=[C:3]1[C:11]([O:13][CH3:14])=[O:12]参加物
3
実験手順
The synthesis is carried out according to the general procedure; for work-up, the resulting precipitate is filtered off with suction and washed twice with water and three times with ethyl acetate. The organic phase of the resulting filtrate is separated off, dried and concentrated. Using 0.22 g (1.07 mmol) of methyl 3-aminothieno[2,3-b]pyridine-2-carboxylate and 0.24 g (3.41 mmol) of sodium nitrite, 84 mg (41% of theory) of the desired product are obtained.
後処理
- filtrationfor work-up, the resulting precipitate is filtered off with suction
- washwashed twice with water and three times with ethyl acetate
- customThe organic phase of the resulting filtrate is separated off
- customdried
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-92077d7b20d8411693216d3d67a73140
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07732477B2
反応ノート
読み込み中…