化工社化工社 化学情報印刷レポート · 研究参考用
Pyridine → 4-fluoro-N-{4-fluoro-3-nitrophenyl}benzenesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | 4-Fluorobenzenesulfonyl chloride | HCID 9588 | — |
| 反応物 | 4-Fluoro-3-nitroaniline | HCID 67768 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-fluoro-N-{4-fluoro-3-nitrophenyl}benzenesulfonamide | HCID 798928 | 80.7% |
反応手順
Pyridine (500 uL, 6.19 mmol) was added to a solution of 4-fluoro-3-nitro-phenylamine (1 g, 6.41 mmol) and 4-fluoro-benzenesulfonyl chloride (1.2 g, 6.19 mmol) in dichloromethane (DCM) (20 mL) and the reaction was stirred at room temperature overnight. The reaction was then partitioned between water and DCM. The organic layer was washed several times with water and concentrated. Recrystalization from ethanol/water gave 1.57 g of the sub-title compound as tan crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07732618B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-6f17df37e00a4352aac9ba84d1fdc378 |
| 出典メモ | uspto-grants-2010_06 |