Butanal → [5-(4-Fluoro-benzenesulfonylamino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester

HRID 15527

反応式

HRID 15527 の反応式
[C:1]([O:5][C:6](=[O:27])[CH2:7][NH:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][S:16]([C:19]2[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=2)(=[O:18])=[O:17])=[CH:11][C:10]=1[NH2:26])([CH3:4])([CH3:3])[CH3:2].[CH:28](=O)[CH2:29][CH2:30][CH3:31]>C(O)C.C(O)(=O)C>[C:1]([O:5][C:6](=[O:27])[CH2:7][N:8]1[C:9]2[CH:14]=[CH:13][C:12]([NH:15][S:16]([C:19]3[CH:20]=[CH:21][C:22]([F:25])=[CH:23][CH:24]=3)(=[O:18])=[O:17])=[CH:11][C:10]=2[N:26]=[C:28]1[CH2:29][CH2:30][CH3:31])([CH3:4])([CH3:2])[CH3:3]

参加物

5

反応物 2

HCID 261ButanalHCID 67199324[2-Amino-4-(4-fluoro-benzenesulfonylamino)-phenylamino]-acetic acid tert-butyl ester

生成物 1

HCID 67201670[5-(4-Fluoro-benzenesulfonylamino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester

試薬・触媒・溶媒 2

HCID 176Acetic Acid触媒HCID 702Ethanol溶媒

反応条件

温度
70 °C

実験手順

The product from step c.) (100 mg, 0.25 mmol) was dissolved in ethanol (5 mL) and treated with acetic acid (2 drops) followed by butyraldehyde (35 uL, 0.39 mmol). The reaction was heated to 70° C. for 18 hours. The reaction mixture was cooled to ambient temperature and concentrated under reduced pressure to give the crude sub-title compound that was used without further purification.

後処理

  1. temperatureThe reaction mixture was cooled to ambient temperature
  2. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-2451222b1e724e918f6a55eac24a9455
出典データセット
uspto-grants-2010_06
特許番号
US07732618B2

関連ノート

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