Sodium Bicarbonate → (3,3-Diethoxy-propyl)-carbamic acid allyl ester

HRID 15529

反応式

HRID 15529 の反応式
[C:1](Cl)(=[O:5])[CH2:2][CH:3]=C.[CH2:7]([O:9][CH:10]([O:14][CH2:15][CH3:16])[CH2:11][CH2:12][NH2:13])[CH3:8].[C:17]([O-])(O)=[O:18].[Na+]>C(Cl)Cl>[CH2:2]([O:3][C:17](=[O:18])[NH:13][CH2:12][CH2:11][CH:10]([O:14][CH2:15][CH3:16])[O:9][CH2:7][CH3:8])[CH:1]=[CH2:5]

参加物

5

反応物 3

HCID 516892Sodium BicarbonateHCID 5210291-Amino-3,3-diethoxypropaneHCID 10975427But-3-enoyl Chloride

生成物 1

HCID 86605042(3,3-Diethoxy-propyl)-carbamic acid allyl ester

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

But-3-enoyl chloride (930 uL, 8.84 mmol) was added slowly to a rapidly stirring mixture of 3,3-diethoxy-propylamine (1.0 g, 6.80 mmol) and NaHCO3 (2 mL of 0.6 M NaHCO3 in water) in DCM (100 mL). The reaction was stirred at room temperature overnight, then partitioned between water and DCM. The organic layer was washed several times with water and concentrated to give the crude sub-title compound that was used without further purification.

後処理

  1. stirringThe reaction was stirred at room temperature overnight
  2. custompartitioned between water and DCM
  3. washThe organic layer was washed several times with water
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-233d52f44e6349a7a7bc1dd57e6b77de
出典データセット
uspto-grants-2010_06
特許番号
US07732618B2

関連ノート

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