関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Butanal | HCID 261 | — |
| 反応物 | [2-Amino-4-(4-fluoro-benzenesulfonylamino)-phenylamino]-acetic acid tert-butyl ester | HCID 67199324 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | [5-(4-Fluoro-benzenesulfonylamino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester | HCID 67201670 | — |
反応手順
Butyraldehyde (3.8 mL, 41.8 mmol) and acetic acid (1.4 mL) were added to a solution of [2-amino-4-(4-fluoro-benzenesulfonylamino)-phenylamino]-acetic acid tert-butyl ester (12.5 g, 26.8 mmol) in EtOH (135 mL), and stirred overnight at 70° C. The reaction mixture was cooled to ambient temperature and concentrated under reduced pressure to give the crude sub-titled compound that was used without further purification. MS calculated for C22H26FN3O4S—H: 446, observed: 446.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07732618B2 |
|---|
| 出典データセット | uspto-grants-2010_06 |
|---|
| ORD ID | ord-7210e5014eab4c069930c927dd1fe75b |
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| 出典メモ | uspto-grants-2010_06 |
|---|
