Potassium Carbonate → {5-[(2,3-Dichloro-benzyl)-(4-fluoro-benzenesulfonyl)-amino]-2-propyl-benzoimidazol-1-yl}-acetic acid tert-butyl ester

関与物質

役割	名称	HCID	仕込み量
反応物	Potassium Carbonate	HCID 11430	—
反応物	Dichlorobenzyl chloride	HCID 76790	—
反応物	[5-(4-Fluoro-benzenesulfonylamino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester	HCID 67201670	—
溶媒	Water	HCID 962	—
溶媒	Acetonitrile	HCID 6342	—
溶媒	Ethyl Acetate	HCID 8857	—
生成物	{5-[(2,3-Dichloro-benzyl)-(4-fluoro-benzenesulfonyl)-amino]-2-propyl-benzoimidazol-1-yl}-acetic acid tert-butyl ester	HCID 67200837	—

反応条件

温度	80 °C

反応手順

2,3-Dichlorobenzyl chloride (0.27 mmol) and K2CO3 (63 mg, 0.45 mmol) were added to a solution of [5-(4-fluoro-benzenesulfonylamino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester (40 mg, 0.09 mmol) in CH3CN (1 mL), and stirred overnight at 80° C. The reaction mixture was diluted with EtOAc and H2O, and then filtered through an Extrelut column. The column was washed with EtOAc, and the filtrate was concentrated. The crude product was carried onto the next reaction without any further purification or characterization.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US07732618B2
出典データセット	uspto-grants-2010_06
ORD ID	ord-fd370e68eb5240ac810f2f74c672b339
出典メモ	uspto-grants-2010_06